7 Best Pain Relief Creams, Pharmacists-Ranked 2025 | U.S. News (2025)

Rankings: Pain Relief Creams and Gels

Rank

Brand

Active/Key Ingredients

(sample product)

Important Considerations

(sample product)

Sample Product

#1

7 Best Pain Relief Creams, Pharmacists-Ranked 2025 | U.S. News (1)

Score:100

Voltaren

Arthritis Pain Gel:

Diclofenac Sodium 1%

  • FSA Eligible

  • NSAID

  • Gel

More

#2

Score:54

Biofreeze

Pain Roll-On:

Menthol 4%

  • FSA Eligible

  • Gel option

  • Cream option

More

#3

Score:40

Aspercreme

With Lidocaine:

Trolamine Salicylate 10%

  • FSA Eligible

  • Gel option

  • Cream option

More

#4

Score:33

Icy Hot

Original Pain Relief No Mess Roll-On:

Menthol 16%

  • FSA Eligible

  • Cream option

  • Gel option

More

#5

Score:18

Bengay

Ultra StrengthTopical Pain Relief Cream:

Camphor 4%

Menthol 10%

More

  • FSA Eligible

  • Gel option

  • Cream option

More

#1

7 Best Pain Relief Creams, Pharmacists-Ranked 2025 | U.S. News (2)

Score:100

Voltaren

Rank
Active/Key Ingredients

Arthritis Pain Gel:

Diclofenac Sodium 1%

Important Considerations
  • FSA Eligible

  • NSAID

  • Gel

More

Sample Product

#2

Score:54

Biofreeze

Rank
Active/Key Ingredients

Pain Roll-On:

Menthol 4%

Important Considerations
  • FSA Eligible

  • Gel option

  • Cream option

More

Sample Product

#3

Score:40

Aspercreme

Rank
Active/Key Ingredients

With Lidocaine:

Trolamine Salicylate 10%

Important Considerations
  • FSA Eligible

  • Gel option

  • Cream option

More

Sample Product

#4

Score:33

Icy Hot

Rank
Active/Key Ingredients

Original Pain Relief No Mess Roll-On:

Menthol 16%

Important Considerations
  • FSA Eligible

  • Cream option

  • Gel option

More

Sample Product

#5

Score:18

Bengay

Rank
Active/Key Ingredients

Ultra StrengthTopical Pain Relief Cream:

Camphor 4%

Menthol 10%

More

Important Considerations
  • FSA Eligible

  • Gel option

  • Cream option

More

Sample Product

Please consult your health care provider for specific guidance on health products that may be appropriate for you. While U.S. News lists the results of the survey, U.S. News does not recommend or endorse any health products listed here. Please see Disclaimer and a Note About Your Health. Read about the survey here.

When you use our links to buy products, we may earn a commission. This does not affect the quality or independence of our editorial content.

Why Trust U.S. News

How we rate OTC Medicines and Health Products

1100+

products evaluated

357

pharmacists surveyed

134

dermatologists surveyed

See our full methodology

See our full methodology

7 Best Pain Relief Creams, Pharmacists-Ranked 2025 | U.S. News (3)

Learn More

Related Articles

Patient Advice

Chronic Pain: Ranking the Most Painful Medical Conditions

Find out which medical conditions experts rank as the most painful. Learn how these conditions are treated and what you can do to manage your pain.

Christine ComizioMay 22, 2025

Fitness

Yoga for Arthritis

Gentle yoga can be a beneficial practice for people with arthritis to help manage pain and stiffness by promoting joint mobility and flexibility.

Jake PanasevichMay 16, 2025

Wellness

Journavx: What to Know About the New Nonopioid Painkiller

This drug may reduce the risk of addiction to pain medications by decreasing reliance on opioids to reduce pain.

Cheyenne BuckinghamMarch 14, 2025

Wellness

Elbow Pain: Tennis and Golfer's Elbow Pain Explained

Learn the signs and treatments for elbow pain caused by overuse and muscle strain – from golfing, tennis or other repetitive movements.

Rock PositanoMarch 5, 2025

Methodology

The Best OTC Medicine & Health Products are based on the reviews of nearly 500 independent pharmacists and dermatologists.

U.S. News partnered with The Harris Poll, a global market research and consulting firm with more than 65 years of experience conducting surveys. For the 2025 rankings, The Harris Poll randomly assigned 133 over-the-counter categories of health or personal care products to 357 pharmacists and 134 dermatologists who practice in the U.S. and asked them to rank their top three brands for each category based on what products they would most recommend to consumers.

Independence and transparency

Across the 133 categories that were evaluated, each category included between five and 10 products representing their respective brands that could be ranked. More than 1,100 products were included in the survey. The products included in each category were selected to represent their respective brands based on input by several independent pharmacists and dermatologists on our

Medical Review Board

. The list of products were finalized by the health editorial team to ensure all products can be purchased without a prescription and are readily available at most pharmacies or pharmacy sections of grocery stores in the U.S.

We independently evaluate the products we recommend. Brands do not pay to be included or ranked in our survey. When you buy through our links, we may earn a commission. The dermatologists and pharmacists who participated in the survey were paid a small honorarium by The Harris Poll for their time.

OTC category winners

Pharmacists and dermatologists selected their top three brands from representative products in each OTC category assigned to them. At least 112 dermatologists evaluated each skincare-related category and at least 108 pharmacists evaluated each of the other categories. For each evaluation, the top-ranked brand received 5 points, the second-place brand was awarded 3 points and the third-place brand earned 1 point. All unranked brands were given 0 points. Points were averaged for each brand. The results were then rescaled so the winner in each category scored 100 points, and the scores for other brands were expressed as percentages of the top score. Brands were then ranked according to their rescaled scores. Scores were rounded to the nearest whole number.

Category winners and brands that scored within the margin of error of the category winner and achieved a score of 80 or higher were given a Gold Badge in that category. The results: 196 brands received a Gold Badge. In total, 849 products are displayed. Brands that received a score of less than 10 were not included in the final display list. See our full methodology here.

7 Best Pain Relief Creams, Pharmacists-Ranked 2025 | U.S. News (2025)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Otha Schamberger

Last Updated:

Views: 6162

Rating: 4.4 / 5 (75 voted)

Reviews: 90% of readers found this page helpful

Author information

Name: Otha Schamberger

Birthday: 1999-08-15

Address: Suite 490 606 Hammes Ferry, Carterhaven, IL 62290

Phone: +8557035444877

Job: Forward IT Agent

Hobby: Fishing, Flying, Jewelry making, Digital arts, Sand art, Parkour, tabletop games

Introduction: My name is Otha Schamberger, I am a vast, good, healthy, cheerful, energetic, gorgeous, magnificent person who loves writing and wants to share my knowledge and understanding with you.